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Infectious laryngotracheitis ILT is an upper respiratory disease of chickens, pheasants, and peafowl caused by the alphaherpesvirus Gallid alpha herpesvirus 1 GaHV-1 , commonly known as infectious laryngotracheitis virus.
ILT is an acute respiratory disease characterized by clinical signs of conjunctivitis, nasal discharge, dyspnea, and lethargy. In severe forms of the disease, hemorrhagic tracheitis together with gasping, coughing, and expectoration of bloody mucus are common. The morbidity and mortality rates of the disease vary depending on the virulence of the strain circulating, the level of virus circulating in the field, and the presence of other respiratory infections.
Since the identification of the disease in the s, ILT continues to affect the poultry industry negatively across the globe. The disease is primarily controlled by a combination of biosecurity and vaccination.
The first commercial vaccines, introduced in the late s and early s, were the chicken embryo origin live attenuated vaccines. The tissue culture origin vaccine was introduced in late s. Recombinant viral vector ILT vaccines were first introduced in the United States in the s, and now they are being used worldwide, alone or in combination with live attenuated vaccines. This review article provides a synopsis of what we have learned about vaccines and vaccination strategies used around the world and addresses knowledge gaps about the virus and host interactions that remain unknown.
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Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract in English , French. Maekawa D, et al. Avian Pathol. Epub Sep 5. PMID: Long-term protection against a virulent field isolate of infectious laryngotracheitis virus induced by inactivated, recombinant, and modified live virus vaccines in commercial layers.
Palomino-Tapia VA, et al. Epub Jan Current and future vaccines and vaccination strategies against infectious laryngotracheitis ILT respiratory disease of poultry. Vet Microbiol. Epub Dec PMID: Review. Avian Dis. Immune responses to infectious laryngotracheitis virus. Coppo MJ, et al. Dev Comp Immunol. Epub Apr 6. Show more similar articles See all similar articles.
Cited by 1 article Infectious laryngotracheitis: Etiology, epidemiology, pathobiology, and advances in diagnosis and control - a comprehensive review. Gowthaman V, et al. Vet Q. Publication types Review Actions. MeSH terms Animals Actions. Substances Viral Vaccines Actions. Full-text links [x] BioOne. Copy Download.
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