Fructooligosaccharides FOS are sugars found naturally at high concentrations in the storage roots of yacon. This study was designed to analyze the beneficial effects of subchronic oral consumption of yacon root flour as a diet supplement in Streptozotocin-induced diabetic Wistar rats. Yacon flour is a natural product obtained by a simple process of dehydration of yacon roots without added preservatives or chemicals. The administration of FOS-rich yacon flour to diabetic rats for 90days did not significantly alter the body weight of animals throughout the experimental period.
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Context: Smallanthus sonchifolius Poepp. Robinson, Asteraceae yacon roots are a natural product recognized by the traditional medicine to treat diabetes-related problems. There are no reports concerning the potential of yacon roots to reduce oxidative stress and ameliorate diabetes complications in diabetic animals. Objective: This work analyzes the in vivo antioxidant activity and beneficial effects of yacon roots, using a model of streptozotocin-induced diabetes in rats.
Biochemical parameters were determined in liver, kidney, and blood at the end of the experimental period. Results: Yacon supplementation to diabetic rats produced a significant decrease in malondialdehyde levels in both liver Hepatic superoxide dismutase and catalase activities were significantly lower in diabetic-treated rats Similar results were observed in kidney.
The treatment of diabetic rats produced an increase of glutathione peroxidase and glutathione levels in liver Plasma cholesterol and triacylglycerol levels and liver fatty acid composition, which were altered in diabetic rats, reverted back to nearly normal with yacon treatment.
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Yan MR, et al. Hypolipidemic effect of Smallanthus sonchifolius yacon roots on diabetic rats: biochemical approach. Habib NC, et al. Chem Biol Interact. Epub Aug PMID: Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius Poepp.
Oliveira GO, et al. Food Chem Toxicol. Epub Jun Dos Santos KC, et al. Oxid Med Cell Longev. Caetano BF, et al. Show more similar articles See all similar articles. J Obes. Cao Y, et al. Antioxidant and Hepatoprotective Potentiality of Randia dumetorum Lam. Kandimalla R, et al. Front Pharmacol. MeSH terms Animals Actions.
Male Actions. Rats Actions. Rats, Wistar Actions. Substances Antioxidants Actions. Plant Extracts Actions. Copy Download.
Yacon Roots (Smallanthus Sonchifolius) Improve Oxidative Stress in Diabetic Rats
Smallanthus sonchifolius yacon , a native plant of South America, was observed to improve lipid profile in rodents and humans. This study aimed to investigate the antiobesity properties of yacon roots in a high-fat-diet HFD model and the underlying mechanisms. HFD Y and HFD Y rats exhibited marked attenuation of weight gain, a decrease in visceral fat pad weight, a restoration of the serum lipid profile and atherogenic index in a dose-dependent manner, being the higher dose more effective. In addition, we found that HFD Y rats showed lower glucose and insulin levels, improved glucose tolerance, and insulin sensitivity. In the second approach, we determined that yacon supplementation potentiates the effects of the HFD reversion to a standard diet.