GENETIQUE BACTERIENNE PDF

Project: Cell-cell communication, division of labor and genetic expression in sporulating Gram-positive bacteria. Project: Characterization of the Vibrio cholerae stress response via the Cpx two-component system and the RpoH alternative sigma factor. Project:: The PlcR regulon in the Bacillus cereus group: cell-cell communication, genetic expression and diversity. Wunder E.

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Our research unit aims at studying peptidoglycan PGN metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process to accompany cell growth and division. We use Helicobacter pylori as a bacterial model since genome analysis indicates a minimal set of genes involved in PGN metabolism and assembly suggesting it might be a simpler model to study PGN metabolism. This seems to be confirmed by our recent work on the PGN hydrolases of H. The long-term goal of this part of my research is to better understand how bacteria coordinate PGN synthesis, and therefore to identify new therapeutic targets, but also to better understand the mechanisms of antibiotic resistance and their associated fitness cost. The study of fitness cost associated with antibiotic resistance is complementary to the discovery of new therapeutic targets as it can result in a better management of existing antibiotics and extend their shelf-live. The second part of our research is aimed at studying the role of PGN in host-microbe interactions.

A4 ZEICHNUNGSRAHMEN PDF

Biology and Genetics of Bacterial Cell Wall

An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis, was constructed by using a twin-pronged approach. Pulsed-field gel electrophoretic analysis enabled cleavage sites for Asn I and Dra I to be positioned on the 4. The resultant contig map was readily correlated with the physical map of the genome via the landmarked restriction sites. Over genes and markers were localized on the integrated map, thus enabling comparisons with the leprosy bacillus, Mycobacterium leprae, to be undertaken. Mycobacterial genomes appear to have evolved as mosaic structures since extended segments with conserved gene order and organization are interspersed with different flanking regions. Repetitive sequences and insertion elements are highly abundant in M.

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