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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane-patches. Pflugers Arch ; Sakmann B, Neher E. Patch clamp techniques for studying ionic channels in excitable membranes. Annu Rev Physiol ;

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Esse contexto rendeu a Robert F. Furchgott, Ferid Murad e Louis J. Esse efeito foi mediado por dois mecanismos distintos: 1. Dimmeler e cols. De fato, Blair e cols. Mimetizando os experimentos em animais, mais tarde os estudos de Dietz e cols. No entanto, Majmudar e cols. Genotipada e sequenciada em por Marsden e cols. No entanto, Fairchild e cols. Philip e cols. Segundo Frandsenn e cols. Potencial Conflito de Interesses.

Fontes de Financiamento. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Vila E, Salaices M. Cytokines and vascular reactivity in resistance arteries. The biological significance of nitric oxide formation from L-arginine. Biochem Soc Trans. Kojda G, Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal.

Biol Chem. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. Endothelial function testing as a biomarker of vascular disease. Pepine CJ The impact of nitric oxide in cardiovascular medicine: untapped potential utility. Am J Med. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol. Cai H. NAD P H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease.

Circ Res. Gao L, Mann GE. Asymmetric dimethylarginine ADMA : an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.

Med Sci Monit. Sessa WC. J Cell Sci. Marletta MA. Nitric oxide synthase: aspects concerning structure and catalysis. Govers R, Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. Stuehr DJ. Structure-function aspects in the nitric oxide synthases. Annu Rev Pharmacol Toxicol. Expression of inducible nitric oxide synthase is increased in patients with heart failure due to ischemic disease. Braz J Med Biol Res.

Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Nitric oxide synthases: structure, function and inhibition. Biochem J. Role of plasmalemmal caveolae in signal transduction. Am J Physiol. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett. Dissecting the interaction between nitric oxide synthase NOS and caveolin: functional significance of the nos caveolin binding domain in vivo.

J Biol Chem. Razani B, Lisanti MP. Caveolin-deficient mice: insights into caveolar function human disease. J Clin Invest. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab. Protective role of endothelial nitric oxide synthase.

J Pathol. Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol. On the mechanism of the nitric oxide synthase-catalyzed conversion of N omega-hydroxyl-L-arginine to citrulline and nitric oxide. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.

Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.

Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Searles CD. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression. Am J Physiol Cell Physiol.

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. Characterization of the human endothelial nitric-oxide synthase promoter. Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. Biochem Biophys Res Commun.

Nitric Oxide. Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding. Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Michel T, Feron O.

Nitric oxide synthases: which, where, how, and why? Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.

J Mol Cell Cardiol.

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